Pankind Scientific Meeting 2025 Booklet

Pankind, Pancreatic Cancer Australia, respectfully acknowledges the Gadigal of the Eora  nation as the Traditional Custodians of this land on which we meet today. We would also like to pay our  respects to Elders past, present and emerging.

Organising Committee

BLEE 2022 (1)

Dr Belinda Lee

MBBS, MRCP (UK), PGDip (Oncology) FRACP

 A/Prof Savio Barretto

A/Prof Savio Barretto

Gastrointestinal and Hepato-Pancreato- Biliary Surgeon, academic and researcher, Flinders University

Prof Anthony Gill

Prof Anthony Gill AM

MBBS MD FRCPA

Welcome from CEO Michelle Stewart

Michelle Stewart

Dear Guests,

On behalf of Pankind, Pancreatic Cancer Australia, it is my great pleasure to welcome you to our 2025 Scientific Meeting.

This year marks an important milestone for Pankind, with $2.5 million invested into pancreatic cancer research, bringing our total research investment to $20.5 million since inception. Research remains our central focus because we know that scientific discovery is the path to improving outcomes and, ultimately, saving lives.

The theme for this year’s meeting  “The Road to Treatment” captures both the momentum and optimism we share. Across Australia and around the world, there is a growing sense of progress as researchers move closer to new treatment options, better detection pathways, and more personalised care. Each contribution from this vibrant scientific community brings us another step forward on that road.

Alongside our research efforts, Pankind provides vital support for people affected by pancreatic cancer. Through our flagship resource “Living with Pancreatic Cancer,” we offer trusted information to help patients and carers navigate diagnosis, treatment and care. Our Support Navigator and partnership with TrialScreen ensure people can access personalised guidance and clinical trial opportunities.

We are proud to fund a surveillance study with the Jreissati Pancreatic Centre at Epworth for those at higher risk, building clarity and structure around early detection. Pankind also advocates for access to genomic profiling and clinical trials.

We are also working to raise awareness in collaboration with the many fantastic organisations dedicated to improving outcomes in pancreatic cancer, because progress is only possible when we move forward together.

Together, these initiatives demonstrate Pankind’s commitment to driving change through world-class research, patient support, and strong collaboration across the pancreatic cancer community.

We are deeply grateful to the scientific community for your passion, persistence and partnership. Your work inspires hope for every person and family affected by this disease.

We look forward to an engaging and inspiring meeting as we continue, together, along the Road to Treatment.

With best wishes,
Michelle Stewart

Chief Executive Officer

2025 Workshop Program

8.30 - 9.00

Arrival and registration

9:00 - 9:10

Welcome and Introductions

9:10 - 10:25

Plenary Session: Global Insights; Advancing Pancreatic Cancer Treatment


Dr Eileen O'Reilly - Memorial Sloan Kettering Cancer Center, USA
Pancreas Cancer 2025: New and Emerging Therapies


Dr Andrew Lowy - University of California, San Diego, USA
Reimagining Surgery for Pancreatic Cancer

10:25 - 11:10

Morning Tea and Posters

11:10 - 12:00

Session 1: Clinical Impact


Prof David Thomas - Omico
The rapidly evolving therapeutic landscape in pancreatic cancer


Prof Jayesh Desai - Peter MacCallum Cancer Center
Innovative early phase therapies for pancreatic cancer

12:00 - 13:00

Session 2: New Treatments and Targeted Therapies

Prof Andrew Scott - Olivia Newton John Cancer Research Institute
Targeting the tumour microenvironment in pancreatic cancer

Prof Claudine Bonder - University of South Australia
Reinvigorating anti-tumour immunity to overcome pancreatic ductal adenocarcinoma

Dr Shona Ritchie - Garvan Institute of Medical Research
Identifying PCSK9 as a potential therapeutic co-target in metastatic pancreatic ductal adenocarcinoma

13:00 - 14:00

Lunch break

14:00 - 15:00 

Session 3: Early Detection


Dr Jean Winter - Flinders University
Exploring the plasma proteome to find biomarkers that can detect early-stage pancreatic ductal adenocarcinoma

Dr Ying Zhu - University of Technology Sydney
Single Extracellular Vesicle Analysis: A Promising Liquid Biopsy Approach for the Early Detection of Pancreatic Cancer

Dr Charbel Sandroussi - University of Sydney
Clinical Implications of Early Detection: Insights from a Surgical Perspective

15:00 - 15:40

Panel discussion

Emerging therapies: What's Next and What's Beyond?

15:40 - 16:00

Afternoon Tea and Posters

16:00 - 16:30

Session 4: Selected Abstracts


Diana Schuhmacher - Garvan Institute of Medical Research
CK2 inhibition as a promising treatment for chemotherapy-resistant pancreatic ductal adenocarcinoma


Layla-Rose Lynam - The University of Queensland
Targeting Epigenetic inhibition as a therapeutic for Pancreatic Cancer


Dr David Herrmann - Garvan Institute of Medical Research
Targeting the NPY/NPY1R signaling axis impairs metastasis and tissue wasting in pancreatic cancer

16:30 - 16:50

2025 Grant Announcement

16:50 - 17:00

Closing Remarks and Discussion

17:00 - 19:00

Networking Drinks

All attendees. Blaxland Ballroom, Swissotel

Plenary Session Speakers

Eileen M. O’Reilly, MD, FASCO

Eileen M. O’Reilly, MD, FASCO

Memorial Sloan Kettering Cancer Center

Andrew Lowy

Andrew Lowy

Professor of Surgery, Chief, Division of Surgical Oncology - Moores Cancer Centre, University of California, San Diego

Session Speakers

David Thomas Omico

Prof. David Thomas

University of New South Wales, Chief Strategy and Science Officer at Omico

Jayesh Desai

Prof. Jayesh Desai

Peter MacCallum Cancer Centre

Prof. Andrew Scott

Prof. Andrew Scott

Olivia Newton-John Cancer Research Institute

Professor Claudine Bonder

Prof. Claudine Bonder PhD

Centre for Cancer Biology

Dr Shona Ritchie

Dr Shona Ritchie PhD

Garvan Institute

Dr Jean Winter

Dr Jean Winter

Flinders University

Dr Ying Zhu

Dr Ying Zhu PhD

University of Technology Sydney

Poster and Oral Abstracts

Pankind previous grant recipients

Development of a non-invasive urine screening test to identify patients with early pancreatic cancer (Marianne Allan Pancreatic Cancer Research Grant)
Principal Investigator: Belinda Lee
Institute: Walter and Eliza Hall Institute of Medical Research

Single extracellular vesicle analysis to identify high-risk pancreatic cancer precursor lesions
Principal Investigator: Ying Zhu
Institute: University of Technology Sydney

Exploring the plasma proteome to find biomarkers that can detect early-stage pancreatic ductal adenocarcinoma
Principal Investigator: Jean Winter
Institute: Flinders University

Enhancing the efficacy of and overcoming resistance to Kras Inhibitors in Pancreatic Cancer
Principal Investigator: Kendelle Murphy
Institute: Garvan Institute of Medical Research 

 

Targeting fibrosis to improve clinical KRAS G12D inhibitor MRTX1133 efficacy in pancreatic cancer
Principal Investigator: Brooke Pereira
Institute: Garvan Institute of Medical Research

 

Novel radiopharmaceutical therapies targeting tumour stroma for treating pancreatic cancer
Principal Investigator: Andrew Scott
Institute: Olivia Newton-John Cancer Research Institute

 

Advancing a new targeted antibody to combat pancreatic cancer
Principal Investigator: Claudine Bonder
Institute: University of South Australia

Development of a blood based test to identify patients with early pancreatic cancer.
Principal Investigator: Dr Belinda Lee
Institute: Walter and Eliza Hall Institute of Medical Research

Receptor-directed precision medicines for pancreatic cancer
Principal Investigator: Prof John Hooper
Institute: Royal Brisbane and Women's Hospital

PemOla: A phase II study combining pembrolizumab and olaparib in metastatic pancreatic adenocarcinoma patients with high tumour mutation burden
Principal Investigator: Dr Daniel Croagh
Institute: Australian Gastro Intestinal Trials Group

 

Targeting oncogenic Pol-II transcription cycles using cyclin-dependent-kinase inhibitors: a new therapeutic approach for pancreatic cancer
Principal Investigator: Prof Ricky Johnstone
Institute: University of Melbourne

 

Targeting lymph-pancreas interactions to treat pancreatic cancer
Principal Investigator: Dr Enyuan Cao
Institute: Monash University

 

New pancreatic cancer treatment involving Aryl Hydrocarbon Receptor (AhR) inhibition in the tumour and microenvironment
Principal Investigator: A/Prof Jennette Sakoff
Institute: Calvary Mater Newcastle

 

Polymer mimics of the TRAIL protein for pancreatic cancer
Principal Investigator: Dr Robert Chapman
Institute: The University of Newcastle

Lighting up the needle in the haystack: targeting malignant stroma to detect early pancreatic cancer on PET.
Principal Investigator: A/Prof David Cavallucci
Institute: Royal Brisbane and Women's Hospital

Development of an early detection biomarker for pancreatic cancer.
Principal Investigator: A/Prof Jason Lee
Institute: QIMR Berghofer Medical Research Institute

A blood test for early detection of pancreatic cancer by single extracellular vesicle analysis.
Principal Investigator: Dr Ying Zhu
Institute: University of Technology Sydney

Identifying metabolic changes in pancreatic fibroblasts during development of pancreatic cancer to facilitate early detection.
Principal Investigator: Dr Zaklina Kovacevic
Institute: The University of Sydney

Trapping pancreatic cancer in a crossfire: investigating a combination treatment approach designed to eradicate pancreatic cancer.
Principal Investigator: Dr Alex Staudacher and Dr Vasilios Liapis
Institute: Central Adelaide Local Health Network

Targeting epigenetic modifying enzymes as a novel therapy for pancreatic cancer.
Principal Investigator: A/Prof Jason Lee
Institute: QIMR Berghofer Medical Research Institute

Advanced analysis of lipid metabolism in pancreatic cancer to reveal new therapeutic targets
Principal Investigator: Prof Nigel Turner
Institute: Victor Chang Cardiac Research Institute

Using precision medicine approaches in pancreatic cancer to improve chemosensitivity via porcupine inhibition.
Principal Investigator: Dr Sean Porazinski
Institute: Garvan Institute of Medical Research

Development of Biomarker Tests for Early Detection/Diagnosis of Pancreatic Cancer.
Principal Investigator: Prof Anubhav Mittal
Institute: The University of Sydney

Advancing a novel ‘early detection’ biomarker for PDAC.
Principal Investigator: Prof Claudine Bonder
Institute: Centre for Cancer Biology

Deciphering the Exosomal RNA Cargo in Pancreatic Cancer-related diabetes using Transcriptmonics: A Novel Approach for Early Detection of Pancreatic Cancer
Principal Investigator: Dr Chamini Perera
Institute: The University of New South Wales

Early Detection and Diagnosis of Pancreatic Cancer using Circulating Tumour Cells.
Principal Investigator: Prof John Rasko
Institute: The University of Sydney

Can the molecules carried by exosomes help to diagnose pancreatic cancer early?
Principal Investigator: Prof Marco Falasca
Institute: Curtin University

3D Human Tumour Explant Culture to Inform Precision Medicine in Pancreatic Cancer.
Principal Investigator: Dr George Sharbeen
Institute: The University of New South Wales

Spatial Transcriptomics a Pathway to Dissecting Barriers to Effective Treatment in Pancreatic Cancer.
Principal Investigator: Prof Phoebe Phillips
Institute: The University of New South Wales

Repurposing FDA/TGA-approved PCSK9 inhibitor evolocumab to enhance immunotherapy outcomes in pancreatic cancer.
Principal Investigator: Prof Paul Timpson and Dr Brooke Pereira
Institute: Garvan Institute of Medical Research

Reprogramming the tumour microenvironment of pancreatic cancer to improve response to therapy
Principal Investigator: Dr Ashleigh Poh
Institute: Olivia Newton-John Cancer Research Institute

Accelerating the uptake of precision medicine in pancreatic cancer using endoscopic ultrasound biopsy.
Principal Investigator: Dr Daniel Croagh
Institute: Monash University

A sequential CRISPR approach to rationally design robust combination treatments in pancreatic cancer
Principal Investigator: Prof Frederic Hollande
Institute: The University of Melbourne

Understanding pancreatic cancer nerve invasion through investigation of the tumour microenvironment to improve patient's pain and disease treatment
Principal Investigator: Dr Katia Nones
Institute: QIMR Berghofer Medical Research Institute

Development of personalised treatment pathways for pancreatic cancer patients
Principal Investigator: Dr Sumit Sahni
Institute: The University of Sydney

2020 Early Detection Initiative Grants

Development of a novel clinical screening tool in people with diabetes and chronic pancreatitis for the early detection of pancreatic cancer.
Principal Investigator: A/Prof Andrew Metz
Institute: Epworth HealthCare

Pancreatic Cancer Early Diagnosis Group - detecting pancreatic cancer earlier before symptoms develop.
Principal Investigator: Prof Rachel Neale
Institute: QIMR Berghofer Medical Research Institute

PRoCESS - Pancreatic Cancer Relatives Counseling and Education Support Service trial
Principal Investigator: A/Prof Vanessa Beesley
Institute: QIMR Berghofer Medical Research Institute

Development of new radioimmunotherapy agent to selectively target and kill pancreatic cancer cells
Principal Investigator: Prof Eva Bezak
Institute: University of South Australia

A novel agent for imaging and treatment of pancreatic cancer
Principal Investigator: Prof John Hooper
Institute: The University of Queensland

Surgical removal of non-metastatic pancreatic cancer – a comparison of European vs Australian practice
Principal Investigator: Prof John Zalcberg
Institute: Monash University

Next steps in harnessing a novel 'tuneable' immune checkpoint to enhance the immunogenicity of anti-pancreatic ductal adenocarcinoma
Principal Investigator: A/Prof Shane Grey
Institute: Garvan Institute of Medical Research

Developing new immunotherapies for pancreatic cancer
Principal Investigator: Dr Tatyana Chtanova
Institute: The University of New South Wales

Development of a non-invasive method of early detection for pancreatic cancer patients using nanotechnology
Principal Investigator: Dr Ying Zhu
Institute: University of New South Wales

Dual targeting of metabolic and immunological aberrations in pancreatic cancer
Principal Investigator: Dr David Herrmann
Institute: Garvan Institute of Medical Research

Starvation of pancreatic tumours by metabolically reprogramming both tumour and stromal cells
Principal Investigator: A/Prof Phoebe Phillips
Institute: The University of New South Wales

Pathway to a novel treatment for pancreatic cancer – targeting the microenvironment (stroma)
Principal Investigator: Prof Minoti Apte
Institute: University of New South Wales

Seeing is believing: Mapping and targeting the extracellular matrix in pancreatic cancer
Principal Investigator: A/Prof Paul Timpson and Dr Thomas Cox
Institute: Garvan Institute of Medical Research

Therapeutic targeting of the potent metastasis suppressor, NDRG1, in pancreatic cancer
Principal Investigator: Dr Zaklina Kovacevic
Institute: University of Sydney

A novel theranostic for pancreatic cancer
Principal Investigator: Prof John Hooper
Institute: University of Queensland

Harnessing a novel ‘tunable’ immune check point to enhance the immunogenicity of anti-pancreatic ductal adenocarcinoma
Principal Investigator: A/Prof Shane Grey
Institute: Garvan Institute of Medical Research

A novel translational pipeline for the introduction of new immune-based therapies targeting localised and metastatic pancreatic ductal adenocarcinoma
Principal Investigator: Prof Brendan Jenkins
Institute: Hudson Institute of Medical Research

A novel therapeutic target in pancreatic cancer: Implications for therapy and diagnosis
Principal Investigator: Prof Marco Falasca
Institute: Curtin University

The Australian Pancreatic Cancer Organoid Biobank
Principal Investigator: Prof Sean Grimmond
Institute: University of Melbourne

<p><strong><a href="/our-impact/research-we-fund/2016-grant-recipients/2016-innovation-grants-associate-professor-phoebe-phillips/">Therapeutically targeting a solute carrier transporter in the stroma of pancreatic cancer</a></strong><br>Principal Investigator: A/Prof Phoebe Phillips<br>Institute: University of New South Wales</p>

<p><strong><a href="/our-impact/research-we-fund/2016-grant-recipients/2016-innovation-grants-professor-des-richardson/">Development of novel agents that target P-glycoprotein resistant pancreatic cancer</a></strong><br>Principal Investigator: Prof Des Richardson<br>Institute: University of Sydney</p>

<p><strong><a href="/our-impact/research-we-fund/2016-grant-recipients/2016-innovation-grants-prof-helge-rasmussen/">A novel therapeutic target in pancreatic cancer: Implications for therapy and diagnosis</a></strong><br>Principal Investigator: Dr Helge Rasmussen<br>Institute: University of Sydney</p>

<p><strong><a href="/our-impact/research-we-fund/2016-grant-recipients/2016-innovation-grants-dr-petranel-ferrao/">Utilising a novel predictor to stratify patients with therapy-resistant pancreatic cancer for treatment with CHK inhibitor drugs to improve responses and outcomes</a></strong><br>Principal Investigator: Dr Petranel Ferrao<br>Institute: University of Melbourne</p>

PanKind Surgical Workshop
Workshop Lead: Professor David Goldstein
Convenor: AGITG

<p><strong><a href="/our-impact/research-we-fund/2015-grant-recipients/2015-accelerator-grants-garvan-institute/">The Australian Pancreatic Cancer Genome Initiative</a></strong><br>Principal Investigator: Prof Anthony Gill<br>Institute: Garvan Institute of Medical Research</p>

<p><strong><a href="/our-impact/research-we-fund/2015-grant-recipients/2015-accelerator-grants-centenary-institute/">A new therapy for pancreatic cancer that improves tumour microenvironment and immune cell penetration</a></strong><br>Principal Investigator: Prof Jennifer Gamble & Prof Mathew Vadas<br>Institute: Centenary Institute</p>

Circulating stromal cells (pancreatic stellate cells) and tumour cells in pancreatic cancer
Principal Investigator: Prof Minoti Apte
Institute: University of New South Wales

Immunology and anti-invasive treatments for pancreatic cancer: A new therapeutic partnership
Principal Investigator: Dr Marina Pajic
Institute: Garvan Institute of Medical Research

Harnessing the power within to conquer pancreatic cancer
Principal Investigator: Dr Emily Colvin
Institute: University of Sydney

Elucidating the mechanism by which MutY-Homolog knockdown kills pancreatic cancer cells
Principal Investigator: Dr George Sharbeen
Institute: University of New South Wales

PanKind National Research Strategy Development
Outcomes: Invest in basic and clinical research to improve outcomes for pancreatic cancer patients.

Jeremy Humphris
Institute: Garvan Institute of Medical Research

Pankind patient and carer resources

Pankind Leadership Team

Peter's Story

Peter has defied the odds to be here today. He was diagnosed with inoperable pancreatic cancer in 2020. Peter’s weight plummeted from 83 kilos down to 59 kilos. He suffered life-threatening blood loss as doctors struggled to biopsy his tumour. Peter’s daughter, Brooke, even brought her wedding forward to make sure her dad would still be there to walk her down the aisle. 

But, just as his family prepared themselves for the worst, a ground-breaking research trial gave Peter a new shot at life.

Suspecting genetics may have played a role in Peter developing the disease, his oncologist organised for him to have germline testing. He put him in contact with Dr Daniel Croagh, a hepatobiliary and pancreatic surgeon based at Monash Medical Centre, who was looking to improve the take-up of molecular profiling in pancreatic tumours. 

Peter’s biopsy identified he had the BRCA mutation (also seen in his germline testing) as well as a high number of mutations within the tumour. He was given Olaparib – a treatment that is particularly effective in people with hypermutated tumours.

The treatment was extraordinarily successful, and Peter went into remission in October 2021.

Peter's Story

Peter's Story

Peter has defied the odds to be here today. He was diagnosed with inoperable pancreatic cancer in 2020. Peter’s weight plummeted from 83 kilos down to 59 kilos. He suffered life-threatening blood loss as doctors struggled to biopsy his tumour. Peter’s daughter, Brooke, even brought her wedding forward to make sure her dad would still be there to walk her down the aisle. 

But, just as his family prepared themselves for the worst, a ground-breaking research trial gave Peter a new shot at life.

Suspecting genetics may have played a role in Peter developing the disease, his oncologist organised for him to have germline testing. He put him in contact with Dr Daniel Croagh, a hepatobiliary and pancreatic surgeon based at Monash Medical Centre, who was looking to improve the take-up of molecular profiling in pancreatic tumours. 

Peter’s biopsy identified he had the BRCA mutation (also seen in his germline testing) as well as a high number of mutations within the tumour. He was given Olaparib – a treatment that is particularly effective in people with hypermutated tumours.

The treatment was extraordinarily successful, and Peter went into remission in October 2021.

Say hello to your pancreas this November

Say hello to your pancreas this November

World Pancreatic Cancer Day is a worldwide platform to speak with one voice and raise awareness together. This year again, Pankind will leverage this global campaign to raise awareness in Australia with a printed ad in The Senior, some pro-bono Out of Home, digital marketing and lighting up in purple landmark buildings around the country.

2025 Meeting Attendees

Thank you to our sponsors

amplia therapeutics
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company of biologists

TO ADD: social links and hashtags

2025 Workshop Program